8
Mar

To what disease increased Haemoglobin (HB) and increased Haematocrit (HCT) lead to, when all other things including RBC are normal count in CBC Report? Is is hazardous to have high levels (more than normal range) of HB and HCT? Of which disease are these symptoms of? To what condition it might lead to?


Answer:
High Hemoglobin= high volume of hemoglobin (protein) that carries oxygen in the blood
high hematocrit= high red cell count(erythrocythemia)
Etiology or cause:
Increase red cell production
-Low oxygen pressure in the blood, like in lung disease, shunts(comunication between venous ans arterial circulation
-Increase epoeitin(hormone that stimulate red cell colony) in the body
Cancer, secondary polycythemias
-Disorders of the bone marrow
Primary polycythemia or rubra vera
-Hormonal causes= testosterone.
Medications= PROPECIA
-Liver disease
hemochromatosis,

Increased red blood cell mass increases blood viscosity and decreases tissue perfusion, potentially predisposing the patient to thrombosis.
Symptoms due to high red blood cell mass usually manifest as plethora or a ruddy complexion.
If the polycythemia is secondary to hypoxia, as in venous-to-arterial shunts or compromised lung and oxygenation, patients can also appear cyanotic.
Symptoms might result from impaired circulation to the central nervous system, and patients present with headaches, lethargy, and confusion or more serious presentations, such as stroke and obtundation.
Congenital heart diseases manifest at birth or in early childhood. In some cases, a family history of congenital heart disease may be present.
Patients with familial hemoglobinopathies with increased oxygen affinity usually have a family history of similar problems in several family members, although significant numbers of patients with congenital polycythemia have no family history of similar disorders.
Chronic pruritus in the absence of a rash is more indicative of a primary myeloproliferative disorder rather than secondary polycythemia.

Always discuss the lab findings with your MD, they’re a great resource of information.


Answer:
Mina,
Hemoglobin –HB - is a protein-based component of red blood cells whose primary role is to transfer the oxygen from the lungs to the rest of the body. Hemoglobin is actually the reason why red blood cells appear red, although oxygen-rich blood is noticeably brighter than the depleted blood returning to the heart and lungs. Fresh hemoglobin is produced in the bone marrow as needed. Whenever the blood is carried into the lungs, these hemoglobin proteins attract whatever oxygen is available and this oxygenated blood then travels throughout the entire bloodstream, releasing oxygen into the various muscles and organs all around the body. When these red blood cells are spent, they’re transferred to the gastrointestinal system for disposal and new red blood cells with hemoglobin take their place in the bloodstream. Higher-than-normal hemoglobin may indicate - congenital heart disease - cor pulmonale = Failure of the right side of your heart due to high blood pressure in the arteries of your lungs (pulmonary hypertension) - pulmonary fibrosis = Condition characterized by scarring or thickening of the tissue between the air sacs (alveoli) in your lungs - polycythemia vera = This is a very rare bone marrow disease in which the body makes too many red blood cells - increased RBC formation associated with excess erythropoietin. A high hemoglobin count usually suggests that you have too many red blood cells. This condition is also called erythrocytosis. It can lead to several complications because it can impair circulation and lead to abnormal clotting. An elevated hemoglobin concentration is usually the result of two mechanisms, which are 1. increased red blood cell production as a compensatory mechanism when blood oxygen carrying capacity is compromised to meet the demand of tissue and 2. Contracted plasma volume resulting in an appearance of greater red cell volume. Because the high hemoglobin can not be considered as a special disorder, it can be only treated as a symptom of some other underlying disease. That is why treating the underlying disease will probably lower the hemoglobin level.
Hematocrit is a blood test that measures the number of red blood cells and the size of red blood cells. It gives a percentage of red blood cells found in whole blood. This test is almost always ordered as part of a complete blood count. Higher than normal hematocrit levels can be seen in people living at high altitudes and in chronic smokers. Dehydration produces a falsely high hematocrit that disappears when proper fluid balance is restored. Some other infrequent causes of elevated hematocrit are lung disease, certain tumours, a disorder of the bone marrow known as polycythemia rubra vera, and abuse of the drug erythropoietin (Epogen) by athletes for blood doping purposes. Other causes might include Burns. Diarrhea. Erythrocytosis.

With respect to Chicky, above, Anaemia is a condition which occurs when you’ve an abnormally LOW amount of red blood cells. My next paragraph is posted for reasons similar to this.

ALL ANSWERS SHOULD BE THOROUGHLY RESEARCHED, IN ANY FORUM AND ESPECIALLY IN THIS ONE. - MANY ANSWERS ARE FLAWED.

The information provided here should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed doctor should be consulted for diagnosis and treatment of any and all medical conditions.

I add a link which has details of values involved in the blood test

http://www.drstandley.com/
labvalues_hematology.shtml

Hope this helps
matador 89


Answer:
It wouldn't be anemia, thats just silly.
(It would be a low count)

But theres a lot of severe illnesses that causes high counts.
unless you took pills that stimulate hb etc
Or if you smoke a lot a lot a lot.

This entry was posted on Sunday, March 8th, 2009 at 7:54 pm and is filed under Cancer Q&A. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or TrackBack URI from your own site.

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